Yang Chen Selected Research

Monoclonal Antibodies

1/2024	[Preparation of mouse monoclonal antibodies against the ectodomain of Western equine encephalitis virus E2 (E2ecto) protein].
11/2023	Boningmycin induces AMPK-mediated endoplasmic reticulum-associated degradation of PD-L1 protein in human cancer cells.
1/2023	Model-Based Investigation of Inadequate Efficacy of Tesnatilimab, an Anti-Natural Killer Group 2 Member D Monoclonal Antibody, in Moderately to Severely Active Crohn Disease.
1/2022	Population pharmacokinetics and exposure-response modeling analyses of guselkumab in patients with psoriatic arthritis.
1/2020	Clinical characteristics of cytomegalovirus gastritis: A retrospective study from a tertiary medical center.
1/2020	Population Pharmacokinetics and Exposure-Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative Colitis.
1/2018	Population Pharmacokinetic Modeling of Guselkumab, a Human IgG1λ Monoclonal Antibody Targeting IL-23, in Patients with Moderate to Severe Plaque Psoriasis.
1/2018	A comprehensive evaluation of exposure-response relationships in clinical trials: application to support guselkumab dose selection for patients with psoriasis.
1/2015	Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration.
8/2014	PLCγ1-PKCγ signaling-mediated Hsp90α plasma membrane translocation facilitates tumor metastasis.

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Yang Chen Research Topics

Disease

296	Neoplasms (Cancer) 05/2024 - 04/2003
79	Inflammation (Inflammations) 04/2024 - 01/2006
72	Infections 05/2024 - 02/2005
45	Neoplasm Metastasis (Metastasis) 03/2024 - 11/2011
32	Stomach Neoplasms (Stomach Cancer) 03/2024 - 03/2014
31	Wounds and Injuries (Trauma) 04/2024 - 09/2012
31	Fibrosis (Cirrhosis) 10/2023 - 11/2016
28	Breast Neoplasms (Breast Cancer) 12/2023 - 11/2013
27	Hepatocellular Carcinoma (Hepatoma) 03/2024 - 11/2013
27	Obesity 05/2023 - 04/2002
25	Carcinogenesis 10/2022 - 07/2008
24	Cardiovascular Diseases (Cardiovascular Disease) 05/2024 - 12/2014
24	Hypoxia (Hypoxemia) 01/2023 - 06/2008
23	Heart Failure 01/2024 - 01/2017
20	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 11/2012
20	Lung Neoplasms (Lung Cancer) 02/2024 - 04/2014
19	Type 2 Diabetes Mellitus (MODY) 05/2024 - 12/2014
19	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024 - 04/2009
19	Pain (Aches) 01/2024 - 01/2006
18	COVID-19 04/2024 - 05/2020
17	Hypertension (High Blood Pressure) 01/2024 - 02/2006
17	Stroke (Strokes) 01/2024 - 01/2013
17	Alzheimer Disease (Alzheimer's Disease) 10/2023 - 01/2013
16	Hemorrhage 04/2024 - 01/2017
16	Body Weight (Weight, Body) 04/2024 - 04/2002
16	Virus Diseases (Viral Diseases) 04/2024 - 06/2011
16	Myocardial Infarction 03/2024 - 06/2014
16	Colonic Neoplasms (Colon Cancer) 01/2023 - 06/2014
15	Carcinoma (Carcinomatosis) 10/2023 - 07/2008
14	Adenocarcinoma of Lung 02/2024 - 01/2017
14	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2023 - 01/2013
13	Atherosclerosis 01/2023 - 11/2009
13	Nasopharyngeal Carcinoma 01/2022 - 06/2013
12	Ischemic Stroke 05/2024 - 10/2019
12	Insulin Resistance 03/2024 - 10/2012
11	Glioma (Gliomas) 05/2024 - 01/2009
11	Adenocarcinoma 03/2024 - 04/2009
11	Necrosis 01/2024 - 02/2016
11	Sepsis (Septicemia) 01/2024 - 01/2016
11	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2023 - 07/2015
10	Non-alcoholic Fatty Liver Disease 01/2024 - 08/2016
10	Esophageal Squamous Cell Carcinoma 01/2024 - 01/2014
10	Cognitive Dysfunction 01/2024 - 02/2012
10	Diarrhea 12/2023 - 01/2017
10	Prostatic Neoplasms (Prostate Cancer) 07/2023 - 04/2003
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 03/2016
9	Chronic Renal Insufficiency 05/2024 - 01/2020
9	Squamous Cell Carcinoma of Head and Neck 04/2024 - 01/2020
9	Colitis 04/2024 - 01/2017
9	Sarcopenia 03/2024 - 01/2022

Drug/Important Bio-Agent (IBA)

111	Proteins (Proteins, Gene)FDA Link 05/2024 - 02/2006
79	Biomarkers (Surrogate Marker)IBA 02/2024 - 04/2009
38	MicroRNAs (MicroRNA)IBA 12/2023 - 12/2008
35	RNA (Ribonucleic Acid)IBA 04/2024 - 01/2011
32	LipidsIBA 03/2024 - 11/2009
32	CytokinesIBA 10/2023 - 01/2012
29	Long Noncoding RNAIBA 02/2024 - 01/2014
26	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 04/2002
25	Messenger RNA (mRNA)IBA 04/2024 - 01/2014
25	InflammasomesIBA 07/2023 - 09/2014
23	Therapeutic UsesIBA 05/2024 - 11/2011
18	EnzymesIBA 05/2024 - 09/2012
18	Indicators and Reagents (Reagents)IBA 05/2024 - 01/2013
18	CholesterolIBA 03/2024 - 01/2015
18	Immune Checkpoint InhibitorsIBA 11/2023 - 01/2018
14	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 01/2006
14	AntioxidantsIBA 12/2023 - 04/2007
14	Circular RNAIBA 01/2023 - 01/2017
13	Hormones (Hormone)IBA 03/2024 - 04/2002
12	AntigensIBA 05/2024 - 06/2012
12	Insulin (Novolin)FDA Link 05/2024 - 04/2002
12	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2023 - 11/2009
12	LigandsIBA 01/2023 - 09/2015
11	Anti-Bacterial Agents (Antibiotics)IBA 04/2024 - 12/2012
11	Monoclonal AntibodiesIBA 01/2024 - 01/2013
11	CollagenIBA 11/2023 - 01/2015
11	LipopolysaccharidesIBA 02/2023 - 01/2013
11	NucleotidesIBA 01/2023 - 11/2013
11	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023 - 03/2014
10	Oxygen (Dioxygen)IBA 04/2024 - 03/2012
10	Cisplatin (Platino)FDA LinkGeneric 01/2024 - 12/2019
10	Paclitaxel (Taxol)FDA LinkGeneric 01/2024 - 04/2009
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2023 - 07/2008
10	Small Interfering RNA (siRNA)IBA 11/2023 - 10/2013
10	Antiviral Agents (Antivirals)IBA 07/2023 - 11/2012
9	VaccinesIBA 05/2024 - 01/2014
9	AntibodiesIBA 05/2024 - 01/2019

Therapy/Procedure

176	Therapeutics 07/2024 - 09/2006
32	Immunotherapy 05/2024 - 07/2015
31	Drug Therapy (Chemotherapy) 04/2024 - 12/2012
15	Length of Stay 04/2024 - 01/2017
15	Chinese Traditional Medicine (Traditional Chinese Medicine) 03/2024 - 10/2013
14	Lasers (Laser) 05/2024 - 11/2012
14	Transjugular Intrahepatic Portasystemic Shunt 05/2023 - 01/2021
13	Aftercare (After-Treatment) 04/2024 - 10/2004
13	Radiotherapy 04/2024 - 08/2013
12	Surgical Portasystemic Shunt (Portosystemic Shunt) 01/2023 - 01/2021
10	Stents 04/2024 - 06/2019
10	Transplantation 09/2022 - 10/2019
9	Photothermal Therapy 05/2024 - 07/2017